Table 3 Univariate and multivariate Cox proportional hazard models for 5-year progression-free survival

From: Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma

Variables

Univariate

Multivariate

 

Hazard ratio (95% confidence interval)

P-value

Hazard ratio (95% confidence interval)

P-value

Gross pattern (ulcerative/fungating)

1.98 (1.63–2.41)

< 0.001

1.39 (1.13–1.72)

0.002

Stage (III, IV/I, II)

4.90 (3.83–6.26)

< 0.001

4.48 (3.40–5.91)

< 0.001

Acetyl-CoA synthetase-2 expression (low/high)

1.79 (1.40–2.29)

< 0.001

1.39 (1.08–1.79)

0.01

Differentiation (poor/well, moderate)

3.50 (2.41–5.09)

< 0.001

1.78 (1.15–2.73)

0.009

Tumor budding (present/absent)

2.35 (1.80–3.07)

< 0.001

1.57 (1.19–2.07)

0.002

Adjuvant chemotherapy (yes/no)

1.45 (1.15–1.83)

0.002

0.62 (0.48–0.80)

< 0.001

CDX2 expression (decreased/retained)

1.78 (1.36–2.32)

< 0.001

1.33 (1.00–1.77)

0.049

Tumor-infiltrating lymphocytes (high/low)

0.69 (0.54–0.89)

0.003

 

0.082

Tumor location (proximal/distal, rectum)

1.25 (1.01–1.56)

0.043

 

0.096

Crohn-like lymphoid reaction (present/absent)

0.73 (0.54–0.99)

0.041

 

0.177

CpG island methylator phenotype (CpG island methylator phenotype-high/CpG island methylator phenotype-low or -negative)

1.53 (1.05–2.24)

0.025

 

0.736

Age (≥65 years/<65 years)

1.18 (0.97–1.43)

0.105

  

Sex (male/female)

0.96 (0.78–1.17)

0.653

  

Luminal necrosis (present/absent)

1.25 (0.87–1.80)

0.235

  

Luminal serration (present/absent)

1.40 (0.89–2.19)

0.147

  

Extraglandular mucin (present/absent)

1.06 (0.79–1.43)

0.693

  

Microsatellite instabiilty (microsatellite intability-high/microsatellite instability-low or microsatellite stable)

0.82 (0.55–1.23)

0.343

  

KRAS mutation (mutant-type/wild-type)

1.05 (0.84–1.32)

0.674

  

BRAF mutation (mutant-type/wild-type)

1.19 (0.72–1.97)

0.494

  

KRT7 expression (expressed/not expressed)

1.13 (0.81–1.59)

0.475

  

KRT20 expression (decreased/retained)

0.96 (0.74–1.26)

0.766

  
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