Table 4 Univariate and multivariate analysis of associations between Ki-67 score and standard variables and cancer-specific survival in 179 women with endometrial cancer
From: Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | |
Age (1 year) | 1.10 | 1.05–1.15 | <0.0001**** | 1.06 | 1.001–1.13 | 0.028* |
Body mass index | ||||||
<30 kg/m2 | 1.00 | — | 0.52 | — | — | — |
≥30 kg/m2 | 1.51 | 0.43–5.25 | ||||
Grade | ||||||
1 | 1.00 | — | 0.014** | — | — | — |
2 | 0.584 | 0.05–6.44 | ||||
3 | 4.975 | 1.17–21.12 | ||||
Stage | ||||||
1 | 1.00 | — | <0.0001**** | 1.00 | — | 0.004** |
2 | 0.96 | 0.12–7.99 | 3.27 | 0.34–31.78 | ||
3 | 7.8 | 3.03–20.11 | 6.44 | 2.07–20.06 | ||
4 | 23.36 | 6.49–84.05 | 16.09 | 2.83–91.36 | ||
Histological type | ||||||
Endometrioid | 1.00 | — | <0.0001**** | 1.00 | — | 0.002** |
Non-endometrioid | 8.16 | 3.27–20.39 | 5.72 | 1.93–16.95 | ||
Lymphovascular space invasion | ||||||
Absent | 1.00 | — | ||||
Present | 4.54 | 2.21–9.33 | <0.0001**** | — | — | — |
Depth of myometrial invasion | ||||||
<50% | 1.00 | — | — | — | — | |
≥50% | 2.46 | 1.03–5.90 | 0.043* | |||
Any adjuvant therapy | ||||||
No | 1.00 | — | 0.202 | — | — | — |
Yes | 2.05 | 0.68–6.19 | ||||
Ki-67 score (10% increase) | 1.31 | 1.07–1.60 | 0.010** | 1.14 | 0.91–1.41 | 0.257 |
