Table 1 Summary of clinical parameters and tissue histology parasite counts by HIV status for patients with histologically diagnosed CM

From: Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients

 

Histologically-confirmed cerebral malaria

 

HIV+

HIV−

P-value

Demographics and history

   

 Age (months)

79 (37–106)

26 (20–43)

0.0023

 Gender (% male)

47%

51%

0.5000

 Onset of symptoms to death

50 (29–57)

78 (52–106)

0.0084

Laboratory

   

 Parasitemia (p × 103/μl)

202 (29–325)

74 (8–424)

0.6350

 Hematocrit (%)

20 (18–26)

20 (15–26)

0.7006

 Lactate (mmol/l)

11.1 (9–12.3)

11.9 (5.9–15.1)

0.4638

 White cell count (cells × 103/μl)

13.6 (11.9–14.7)

11.2 (8.8–18.4)

0.6334

 Platelets (cellsx103/μl)

77 (36–144)

50 (26–83)

0.0592

Tissue histology counts a

  

P-value b

 Brain (% vessels parasitized)

82%

72%

0.0907

 Brain (pp/100 capillaries)c

371 (169–473)

219 (92–319)

0.1289

 Lung (pp/10 hpf)

26 (14–115)

30 (19–75)

0.7917

 Heart (pp/10 hpf)

85 (7–128)

12 (5–34)

0.0110

 Stomach (pp/10 hpf)

116 (16–567)

51 (13–120)

0.3389

 Jejunum (pp/10 hpf)

188 (53–1983)

87 (31–454)

0.2428

 Ileum (pp/10 hpf)

110 (3–276)

47 (13–86)

0.3609

 Colon (pp/10 hpf)

215 (51–695)

53 (14–405)

0.1904

 Spleen (pp/10 hpf)

170 (70–222)

16 (4–85)

0.0046

 Skin (pp/10 hpf)

105 (0–1185)

94 (30–144)

0.9264

  1. aAll continuous data shown as median [interquartile range] with Mann–Whitney statistical tests.
  2. bMann–Whitney with Bonferroni correction for multiple testing (11 tests).
  3. cTissue histology counts are in pigmented (ie, late trophozoite/schizont) parasites (pp). Italic values represent the numbers that had significant P-values after correction.
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