Figure 5
From: microRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis
All melanocytic tumors with Spitz morphology expressed miR-211. Representative serial sections (hematoxylin and eosin) followed by fluorescent miRNA in situ hybridization are shown for Spitz nevus (a and b), atypical Spitz tumor (c and d) and spitzoid melanoma (e and f). The SM shown in panel (f) (case no. 30) expressing miR-211 was diagnosed as 2.5 mm melanoma (T3a) on the right calf of a 2-year-old girl; she has had no recurrence or metastasis after 4 years. Kruskal–Wallis test confirmed no statistical difference in miR-211 expression between the diagnostic groups for all lesions tested (g). Original magnification: (a–f), × 100.
