Figure 1 | Modern Pathology

Figure 1

From: Prognostic impact of MYC protein expression in central nervous system diffuse large B-cell lymphoma: comparison with MYC rearrangement and MYC mRNA expression

Figure 1

Representative example of primary central nervous system diffuse large B-cell lymphoma. (a) Hematoxylin and eosin staining showing large neoplastic cells with prominent nucleoli (original magnification, × 400). (b) MYC staining showing a high percentage of cells with positive protein expression (original magnification, × 400). (c) RNA in situ hybridization analysis showing positive MYC mRNA expression (original magnification, 400 × ). (d) MYC rearrangement shown by FISH (one split signal, red and green, and one fused signal). FISH, fluorescence in situ hybridization.

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