Table 1 Relationship between clinicopathological features of patients and MYC protein expression
Characteristics | Total (n=74) | MYC protein expression | P-value | MYC mRNA expression | P-value | ||
|---|---|---|---|---|---|---|---|
Negative (n=25) | Positive (n=49) | Negative (n=58) | Positive (n=16) | ||||
Sex, n (%) | 0.027 | 0.713 | |||||
Male | 40 (54) | 18/25 (72) | 22/49 (45) | 32 (55) | 8 (50) | ||
Female | 34 (46) | 7/25 (28) | 27/49 (55) | 26 (45) | 8 (50) | ||
Age, years | 0.164 | 0.807 | |||||
Median (range) | 58 (19-82) | 58 (19–79) | 60 (25–82) | ||||
<60, n (%) | 39 (53) | 16/25 (64) | 23/49 (47) | 31/58 (53) | 8/16 (50) | ||
≥60, n (%) | 35 (47) | 9/25 (36) | 26/49 (53) | 27/58 (47) | 8/16 (50) | ||
Performance status, n (%) | 0.463 | 0.750 | |||||
ECOG <2 | 17 (23) | 7/25 (28) | 10/49 (20) | 14/58 (24) | 3/16 (19) | ||
ECOG ≥2 | 57 (77) | 18/25 (72) | 39/49 (80) | 44/58 (76) | 13/16 (81) | ||
Serum lactate dehydrogenase, n (%) | 0.455 | 1 | |||||
Normal | 48 (71) | 19/25 (76) | 29/43 (67) | 38/54 (70) | 10/14 (71) | ||
Elevated | 20 (29) | 6/25 (24) | 14/43 (33) | 16/54 (30) | 4/14 (29) | ||
IPI, n (%) | 0.045 | 1 | |||||
<3 Points | 57 (84) | 24/25 (96) | 33/43 (77) | 45/54 (83) | 12/14 (86) | ||
≥3 Points | 11 (16) | 1/25 (4) | 10/43 (23) | 9/54 (17) | 2/14 (14) | ||
Hans algorithm, n (%) | 0.003 | 0.499 | |||||
Germinal center phenotype | 15 (20) | 10/25 (40) | 5/49 (10) | 13/58 (22) | 2/58 (13) | ||
Non-germinal center phenotype | 59 (80) | 15/25 (60) | 44/49 (90) | 45/58 (78) | 14 (88) | ||
CD10 protein expression, n (%) | 0.400 | 1 | |||||
Negative | 68 (92) | 22/25 (88) | 46/49 (94) | 53/58 (91) | 15/16 (94) | ||
Positive | 6 (8) | 3/25 (12) | 3/49 (6) | 5/58 (9) | 1/16 (6) | ||
BCL6 protein expression, n (%) | 1 | 1 | |||||
Negative | 10 (14) | 3/25 (12) | 7/49 (14) | 8/58 (14) | 2/16 (13) | ||
Positive | 64 (86) | 22/25 (88) | 42/49 (86) | 50/58 (86) | 14/16 (88) | ||
MUM1 protein expression, n (%) | 0.005 | 1 | |||||
Negative | 11 (15) | 8/25 (32) | 3/49 (6) | 9/58 (16) | 2/16 (13) | ||
Positive | 63 (85) | 17/25 (68) | 46/49 (94) | 49/58 (85) | 14/16 (88) | ||
MYC | |||||||
MYC protein expression | — | ||||||
Mean % (s.d.) | 48.8 (21.6) | NA | NA | 43.8 (18.5) | 67.2 (22.5) | 0.042 | |
<44, n (%) | 25 (34) | NA | NA | 23/58 (40) | 2/16 (13) | ||
≥44, n (%) | 49 (66) | NA | NA | 35/58 (60) | 14/16 (88) | ||
MYC mRNA expression | 0.042 | — | |||||
Median (min, max) | 34.2 (1.0, 207.5) | 24.9 (1.0, 102.1) | 45.1 (1.3, 207.5) | NA | NA | ||
<63.5, n (%) | 58 (78) | 23/25 (92) | 35/49 (71) | NA | NA | ||
≥63.5, n (%) | 16 (22) | 2/25 (8) | 14/49 (29) | NA | NA | ||
MYC translocation, n (%) | 0.166 | 0.081 | |||||
Negative | 63 (93) | 22/22 (100) | 41/46 (89) | 50/52 (96) | 13/16 (81) | ||
Positive | 5 (7) | 0/22 (0) | 5/46 (11) | 2/52 (4) | 3/16 (19) | ||
BCL2 | |||||||
BCL2 protein expression | |||||||
Median (min, max) | 90 (5.0, 99.0) | 80 (5.0, 95.0) | 90 (5.0, 99.0) | 0.214 | 80 (5.0, 95.0) | 90 (5.0, 99.0) | 1 |
<70, n (%) | 20 (27) | 9/25 (36) | 11/49 (22) | 16/58 (28) | 4/16 (25) | ||
≥70, n (%) | 54 (73) | 16/25 (64) | 38/49 (78) | 42/58 (72) | 12/16 (75) | ||
BCL2 translocation, n (%) | — | — | |||||
Negative | 5 (100) | 0 (0) | 0/5 (0) | 0/2 (0) | 0/3 (0) | ||
Positive | 0 (0) | 0 (0) | 0/5 (0) | 0/2 (0) | 0/3 (0) | ||
