Table 2 Comparison of clinical parameters at the time of kidney biopsy and decline rate of renal function according to the Oxford classification and glomerular IgG deposits

From: Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy

 

At the time of biopsy

Rate of renal function decline (linear regression)

 

Mean arterial pressure (mm Hg)

Urinary protein-to-creatinine ratio

Estimated glomerular filtration rate (ml/min per 1.73 m2)

Univariate (ml/min per 1.73 m 2 per year)

Mutivariate β (s.d.)a

M0

93.3 (83.3–100.7)

0.6 (0.0–1.3)

89.1 (73.0–104.9)

0.4 (0.2–1.0)

 

M1

93.3 (84.7–100.0)

0.7 (0.0–1.9)

82.8 (62.9–96.9)

0.5 (0.2–1.3)

−0.07 (0.34)

P-value

0.42

0.04

<0.001

0.03

0.11

E0

92.7 (83.3–100.8)

0.6 (0.0–1.4)

85.7 (66.5–102.5)

0.5 (0.2–1.1)

 

E1

93.3 (85.0–100.0)

1.9 (0.2–3.4)

75.6 (61.3–89.0)

0.7 (0.3–2.4)

−0.05 (0.72)

P-value

0.53

<0.001

0.01

0.13

0.24

S0

93.3 (83.3–100.0)

0.1 (0.0–0.8)

86.8 (68.4–102.5)

0.3 (0.1–0.6)

 

S1

93.3 (86.5–100.0)

1.2 (0.4–1.9)

84.1 (64.3–101.2)

0.8 (0.5–1.8)

−0.16 (0.35)

P-value

0.26

<0.001

0.7

<0.001

<0.001

T0

93.3 (84.5–100.0)

0.6 (0.0–1.4)

89.1 (70.7–103.5)

0.4 (0.2–1.0)

 

T1

93.3 (85.8–100.0)

0.7 (0.0–2.1)

78.2 (62.1–94.2)

0.6 (0.3–1.2 )

 

T2

96.7 (86.0–101.8)

1.3 (0.1–3.7)

42.3 (36.5–56.7)

8.0 (1.2–10.8)

−0.19 (1.60)

P-value

0.71

<0.001

<0.001

<0.001

<0.001

G grade 0

93.3 (84.5–100.0)

0.5 (0.0–1.3)

86.0 (67.9–102.1)

0.4 (0.2–0.9)

 

G grade 1

93.3 (84.0–100.0)

0.9 (0.0–1.8)

80.2 (62.3–100.0)

0.6 (0.3–2.3)

 

G grade 2+3

93.3 (90.0–101.7)

1.6 (0.6–3.6)

79.8 (63.8–89.0)

2.3 (0.6–6.7)

−0.16 (0.33)

P-value

0.38

<0.001

0.02

<0.001

<0.001

  1. Abbreviations: E0, absence of endocapillary; E1, presence of endocapillary hypercellularity; G grade 0, no or trace IgG deposits; G grade 1, mild IgG deposits; G grade 2, moderate IgG deposits; G grade 3, marked IgG deposits; M0, mesangial hypercellularity score of ≤0.5; M1, mesangial hypercellularity score >0.5; S0, absence of segmental glomerulosclerosis; S1, presence of segmental glomerulosclerosis; T0, tubular atrophy/interstitial fibrosis ≤25% of cortical area; T1, tubular atrophy/interstitial fibrosis 26–50% of cortical area; T2, tubular atrophy/interstitial fibrosis >50% of cortical area.
  2. Note: Values are expressed as median (interquartile range).
  3. Calculation of mean arterial pressure, estimated glomerular filtration rate, and proteinuria is detailed in the text.
  4. aMutivariate models are adjusted for initial estimated glomerular filtration rate, mean arterial pressure, and proteinuria.
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