Table 3 Comparison of clinical parameters at the time of kidney biopsy and decline rate of renal function according to the other immunofluorescence deposits

From: Glomerular IgG deposition predicts renal outcome in patients with IgA nephropathy

 

At the time of biopsy

Rate of renal function decline (linear regression)

 

Mean arterial pressure (mm Hg)

Urinary protein-to-creatinine ratio

Estimated glomerular filtration rate (ml/min per 1.73 m2)

Univariate (ml/min per 1.73 m 2 per year)

Mutivariate β (s.d.)a

IgM (−)

93.3 (84.5–99.0)

0.5 (0.0–1.4)

86.8 (66.7–102.5)

0.4 (0.1–1.2)

 

IgM (+)

93.3 (86.3–103.3)

0.7 (0.0–1.7)

82.6 (65.8–97.2)

0.5 (0.2–1.1)

−0.01 (0.40)

P-value

0.01

0.06

0.10

0.14

0.90

C1q (−)

93.3 (84.8–100.0)

0.6 (0.0–1.5)

85.2 (67.6–101.7)

0.5 (0.2–1.1)

 

C1q (+)

96.0 (88.3–100.0)

1.1 (0.1–2.1)

73.1 (57.3–101.3)

0.6 (0.2–1.6)

−0.004 (0.82)

P-value

0.50

0.09

0.19

0.22

0.92

C3 (−)

93.3 (86.7–103.0)

0.9 (0.0–1.7)

85.0 (67.9–102.1)

0.4 (0.2–0.9)

 

C3 (+)

93.3 (84.2–100.0)

0.5 (0.0–1.5)

84.9 (66.3–101.3)

0.5 (0.2–1.2)

−0.02 (0.51)

P-value

0.11

0.22

0.74

0.45

0.65

C4 (−)

93.3 (84.8–100.0)

0.6 (0.0–1.5)

85.0 (67.2–101.4)

0.5 (0.2–1.1)

 

C4 (+)

95.3 (90.7–104.8)

0.6 (0.0–2.4)

83.6 (54.7–103.3)

0.3 (0.1–1.4)

−0.01 (0.90)

P-value

0.17

0.56

0.42

0.50

0.72

  1. Abbreviations: C1q (−), absence of C1q deposits; C1q (+), presence of C1q deposits; C3 (−), absence of C3 deposits; C3 (+), presence of C3 deposits; C4 (−), absence of C4 deposits; C4 (+), presence of C4 deposits; IgM (−), absence of IgM deposits; IgM (+), presence of IgM deposits.
  2. Note: Values are expressed as median (interquartile range).
  3. Calculation of mean arterial pressure, estimated glomerular filtration rate, and proteinuria is detailed in the text.
  4. aMutivariate models are adjusted for initial estimated glomerular filtration rate, mean arterial pressure, and proteinuria.
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