Table 1 Clinicopathologic features
From: Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas
Histotype | Mean, median age (range) | Germline testing | BRCA1/2 germline mutations (% of those tested) | Other non-BRCA germline mutations (% of those tested) | NACT | STIC | EMOSIS |
|---|---|---|---|---|---|---|---|
High-grade serous carcinoma (n=138) | 60, 60 (31–85) | n=91 | 35% (DEL) 1% (VUS) | 1% (DEL) 9% (VUS) | 36% | 22% | 11% |
Classic (n=40) | 60, 61 (31–77) | n=24 | 24% (DEL) | 12% (VUS) | — | 22% | 5% |
Non-classic (n=40) | 57, 58 (38–70) | n=29 | 50% (DEL) | 3% (VUS) | — | 13% | 8% |
Endometrioid carcinoma (n=12) | 51, 50 (38–74) | n=6 | 0% | 0% | 0% | 0% | 60% |
Clear cell carcinoma (n=10) | 53, 51 (45–68) | n=9 | 0% | 11% (DEL) 11% (VUS) | 0% | 0% | 56% |
Low-grade serous carcinoma (n=7) | 63, 68 (48–79) | n=4 | 0% | 25% (VUS) | 0% | 0% | 0% |
Mucinous carcinoma (n=4) | 37, 34 (25–53) | n=4 | 25% (DEL) | 0% | 0% | 0% | 25% |
Carcinosarcoma (n=2) | 77 (74–79) | n=1 | 0% | 0% | 0% | 0% | 100% |
Undifferentiated carcinoma (n=1) | 57 | n=0 | n/a | n/a | 0% | 0% | 100% |
