Table 2 Mutations in DNA repair pathway genes
From: Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas
Histotype | HR | BRCA1/2 | Non-BRCA HR | MMR | NER | |
|---|---|---|---|---|---|---|
High-grade serous carcinoma (n=138) | 45% | 25% | 10% | ATM (6), BRIP1 (5), FANCC, FANCE, FANCG | 6% | 1% |
 Classic (n=40) | 28% | 8% | 8% | ATM, FANCC, FANCE | 5% | 3% |
 Non-classic (n=40) | 70% | 45% | 10% | ATM (2), BRIP1 (2) | 8% | 0% |
Endometrioid carcinoma (n=12) | 25% | 0% | 25% | ATM (2), RAD21 | 17% | 17% |
Clear cell carcinoma (n=10) | 30% | 20% | 10% | ATM | 0% | 0% |
Low-grade serous carcinoma (n=7) | 0% | 0% | 0% | Â | 0% | 0% |
Mucinous carcinoma (n=4) | 25% | 25% | 0% | Â | 0% | 0% |
