Table 3 Correlation between germline and somatic BRCA1/2 mutations in HGSC

From: Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas

  

BRCA1

BRCA2

Histotype

Germline testing

Germline mutation

Present in tumor

Evidence of somatic inactivation

Germline mutation

Present in tumor

Evidence of somatic inactivation

High-grade serous carcinoma (n=138)

n=91

n=27

n=23

n=10

n=5

n=5

n=3

Classic (n=40)

n=24

n=4

n=2

n=1

n=2

n=2

n=1

Non-classic (n=40)

n=29

n=13

n=12

n=4

n=2

n=2

n=1

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