Table 2 Correlation of melanoma-FISH and myPath gene expression score with the expert histopathologic interpretation
Histopathology | Total | 95% CI | ||||
|---|---|---|---|---|---|---|
Malignant | Benign | |||||
(A) Unequivocal cases | ||||||
FISH | ||||||
Positive | 14 | 0 | 39 | Sensitivity | 93% | 0.66–0.99 |
Negative | 1 | 24 | Specificity | 100% | 0.83–1.00 | |
Agreement | 97% | |||||
myPath | ||||||
Malignant | 8 | 1 | 39 | Sensitivity | 62% | 0.32–0.85 |
Benign | 5 | 21 | Specificity | 95% | 0.75–0.99 | |
Indeterminate | 2 | 2 | Agreement | 83% | ||
Favor malignant | Favor benign | Ambiguous | Total | 95% CI | |||
|---|---|---|---|---|---|---|---|
(B) Challenging cases | |||||||
FISH | |||||||
Positive | 15 | 5 | 3 | 78 | Sensitivity | 56% | 0.36–0.74 |
Negative | 12 | 25 | 18 | Specificity | 83% | 0.65–0.94 | |
Agreement | 70% | ||||||
myPath | |||||||
Malignant | 13 | 4 | 3 | 78 | Sensitivity | 52% | 0.32–0.72 |
Benign | 12 | 16 | 18 | Specificity | 80% | 0.56–0.93 | |
Indeterminate | 3 | 9 | 0 | Agreement | 64% | ||
(C) All cases | |||||||
FISH | |||||||
Positive | 29 | 5 | 3 | 117 | Sensitivity | 69% | 0.53–0.82 |
Negative | 13 | 49 | 18 | Specificity | 91% | 0.79–0.97 | |
Agreement | 81% | ||||||
myPath | |||||||
Malignant | 21 | 5 | 3 | 117 | Sensitivity | 55% | 0.38–0.71 |
Benign | 17 | 37 | 18 | Specificity | 88% | 0.74–0.96 | |
Indeterminate | 5 | 11 | 0 | Agreement | 73% | ||
