Table 5 Correlation of melanoma-FISH with low cutoff values (including FISH-‘borderline positive’ cases as positive) with histopathologic interpretation (A—unequivocal cases; B—challenging cases; C—all cases) and with myPath gene expression score (D—all cases)

From: Comparison between melanoma gene expression score and fluorescence in situ hybridization for the classification of melanocytic lesions

 

Histopathology

Total

  

95% CI

 

Malignant

Benign

    

(A) Unequivocal cases

 FISH (low cutoffs)

Positive

14

5

39

Sensitivity

93%

0.66–0.99

Negative

1

19

 

Specificity

79%

0.57–0.92

    

Agreement

85%

 
 

Favor malignant

Favor benign

Ambiguous

    

(B) Challenging cases

 FISH (low cutoffs)

Positive

20

12

13

78

Sensitivity

74%

0.53–0.88

Negative

7

18

8

 

Specificity

60%

0.41–0.77

     

Agreement

67%

 

(C) All cases

 FISH (low cutoffs)

Positive

34

17

13

117

Sensitivity

81%

0.65–0.90

Negative

8

37

8

 

Specificity

69%

0.54–0.80

     

Agreement

74%

 
 

FISH (low cutoffs)

Total

Agreement

 

Positive

Negative

  

(D) All cases

 myPath

Malignant

22

7

117

59%

Benign

34

38

  

Indeterminate

8

8

  
  1. Statistic parameters calculated on non-indeterminate cases.
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