Figure 1
From: Anaplastic sarcomas of the kidney are characterized by DICER1 mutations
Anaplastic sarcoma of the kidney. (a) Small cysts surrounded by the stromal component, showing marked pleomorphism in (b); (c) anaplastic changes in the stroma and two islands of cartilage, one (upper) showing anaplastic changes; (d) an island of cartilage in the blastema-like area; (e) Case 8 H&E stained section at × 10 shows multifocal islands of cartilage and small cysts in the blastema-like area with necrosis. (f) Case 9 H&E stained section at × 200 shows a predominantly round and ovoid cell population expanding the wall of a cystic structure, which is lined by hobnail epithelium (black arrow). Marked nuclear pleomorphism features in this anaplastic sarcoma (white arrows). (g–j) Case 5. (g) Areas showing prominent rhabdomyoblastic differentiation. (h) A similar area with rhabdomyoblastic differentiation; (i) a spindle cell component of the tumor with some pleomorphic cells; (j) a mixture of areas with spindle cell and rhabdomyoblastic differentiation.
