Figure 4
From: Anaplastic sarcomas of the kidney are characterized by DICER1 mutations
TP53 status is altered in a subset of anaplastic sarcomas of the kidney. (a) Immunohistochemistry staining. Case 1 shows strong positivity in ~50% of tumor cells; case 2 is negative; case 3 is negative; case 4 shows strong positivity in 75–80% of tumor cells; case 5 shows strong positivity in ~30% of tumor cells; case 6—strong positivity in 25–30% of tumor cells; case 7—at × 40 magnification, negative; case 8—moderate positivity in ~85% of tumor cells; case 9—over 90% of cells show very strong positivity. Scale bar is shown for cases 1–6, 8, and 9. (b) Damaging TP53 mutations were identified either by HaloPlex and/or Sanger sequencing.
