Figure 2
From: A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms
Interphase FISH detection of BRAF rearrangement in arcina-type carcinomas. Representative images for each FISH signal patterns. (a) FISH negative for BRAF rearrangement, showing fusion signals of 5′ and 3′ BRAF; (b) FISH positive for BRAF rearrangement—‘broken apart’ signal pattern (red and green signals separated by a gap); (c) FISH positive for BRAF rearrangement—‘single orange (3′BRAF)’ signal pattern, which indicates the loss of 5′ BRAF but preservation of the 3′ BRAF coding the kinase domain.
