Table 1 Twelve acinar-type carcinomas with BRAF fusions
From: A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms
Case ID | Primary tumor site | Histologic diagnosis | FISH % of positivity | FISH signal pattern | BRAF fusion (5′ partner exon-BRAF exon) | Predicted chromosomal rearrangement | pERK IHC |
|---|---|---|---|---|---|---|---|
1_4 | Pancreas | Pure ACC | 99% | F+single 3′ BRAF | GATM1-BRAF (e2-e11) | t(7;15)(q34;q21) | Positive |
1_8 | Pancreas | Pure ACC | 97% | F+single 3′ BRAF | HERPUD1–BRAF (e4-e7) | t(7;16)(q34;q13) | Positive |
1_10 | Pancreas | Pure ACC | 89% | Broken-apart ±F | n/a | n/a | Positive |
2_2 | Pancreas | Pure ACC | 90% | F+single 3′ BRAF | SND1–BRAF (e10–e9) | inv(7)(q31q34) | Positive |
2_3 | Pancreas | Pure ACC | 100% | F+ broken-apart | HERPUD1–BRAF (e6–e7) | t(7;16)(q34;q13) | Positive |
1_18 | Pancreas | Mixed ACC/NE | 95% | F+single 3′ BRAF | ZSCAN30-BRAF (e3–e10) | t(7;19)(q34;q12) | Positive |
2_13 | Pancreas | Mixed ACC/NE | 95% | F+single 3′ BRAF | GIPC2-BRAF (e3–e10) | t(1;7)(p31;q34) | Positive |
1_25 | Pancreas | Mixed ACC/D | 38% | F+ broken-apart | SND1–BRAF (e14–e11) | inv(7)(q31q34) | Positive |
1_26 | Pancreas | Mixed ACC/D | 73% | F+single 3′ BRAF | SND1–BRAF (e10–e11) | inv(7)(q31q34) | Positive |
1_28 | Pancreas | Mixed ACC/D | 68% | F+ broken-apart | SND1–BRAF (e9–e9) | inv(7)(q31q34) | Focal |
2_16 | Liver | Mixed ACC/D | 60% | Broken-apart, no F | SND1–BRAF (e14–e9) | inv(7)(q31q34) | Positive |
2_17 | Pancreas | Mixed ACC/NE/D | 83% | Broken-apart ±F | SND1–BRAF (e9–e9) | inv(7)(q31q34) | Positive |
