Table 3 Genetic features of mesothelioma in study patients

From: Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma

Genetic Abnormality

All histologic types

 

Epithelioid mesotheliomas

 
 

Patients≤35

n=36 (%)

Patients >35

n=48 (%)

P-value

Patients≤35

n=28 (%)

Patients >35

n=27 (%)

P-value

CDKN2A (P16) a

 Deletion

3 (17)

19 (54)

0.01

2 (14)

12 (60)

0.01

 No deletion

15 (83)

16 (46)

 

12 (86)

8 (40)

 

NF2 a

 Deletion

12 (67)

25 (76)

0.53

9 (64)

15 (79)

0.44

 No deletion

6 (33)

8 (24)

 

5 (36)

4 (21)

 

BAP1 expression

 Lost

8 (22)

21 (44)

0.06

8 (29)

12 (44)

 

 Retained

28 (78)

27 (56)

 

20 (71)

15 (56)

0.27

  1. aComplete FISH data were available in 18 of 36 young patients in the young cohort, including 14 epithelioid tumors; FISH data regarding CDKN2A and NF2 status were available in 35 and 33 older patients, respectively, including 20 and 19 patients with epithelioid mesothelioma.
Back to article page