Figure 2

Complete loss of SOX2 expression in high-grade intraepithelial neoplasia observed in a case of SOX2-negative esophageal squamous cell carcinoma (patient 7). Although the non-neoplastic squamous epithelium (np) is positive for SOX2, high-grade intraepithelial neoplasia lacks its expression. SOX2 immunostaining, × 100.