Figure 3

Histologic resolution/regression in patient 5. (a) Initial presenting biopsy at the time of liver failure with severe centrizonal scarring with central vein occlusion (asterisk), H&E stain. (b) Initial biopsy with many ballooned hepatocytes and Mallory–Denk bodies, H&E stain. (c) Initial biopsy with two-tone trichrome staining, highlighting centrizonal scar and obliterated vein (asterisk), trichrome stain. (d) Follow-up biopsy, three years after clinical resolution, without steatosis or ballooned hepatocytes. There are thin fibrous septa stretching from the central zones with mild/moderate portal and lobular inflammation, H&E stain. (Original magnification: (a): × 100; (b): × 200; (c, d): × 100). H&E, hematoxylin and eosin.