Figure 2

APC mutations in colorectal carcinomas (a) and colorectal polyps (b). Selected regions of the APC gene are shown including OD=oligomerization domain, Armadillo repeats, 15AA repeats, MCR=mutational cluster region, 20AA repeats, EB1-binding site and hDLG region. In colorectal carcinomas in (a) red circles represent BRAF wild-type colorectal cancer, blue circles BRAF mutant microsatellite unstable colorectal cancer, and green circles BRAF mutant microsatellite stable colorectal cancer. In colorectal polyps in (b) red circles represent conventional adenomas (tubular adenoma, tubulovillous adenoma), blue circles sessile serrated adenoma and sessile serrated adenoma with dysplasia, and green circles traditional serrated adenomas and traditional serrated adenomas with dysplasia.