Table 1 Case Characteristics

From: Genomic analysis of follicular dendritic cell sarcoma by molecular inversion probe array reveals tumor suppressor-driven biology

 

Clinical information

Genomic information

Sample number

Age (years)

Sex

Tumor site

Clinical notes/follow-up

Total calls

% Genome altered

Tumor content (%)

Clonal burden (%)

Clonal diversity?

Griffin et al case #

% Concordance (# calls) for copy-number alterations

1

39

Male

Peri-duodenum, metastasis to bile duct

SR then XRT at time of primary diagnosis; CT for multiple LR and M beginning at 11 months; DFD at 37 months after first diagnosis

69

62

75

ND

ND

4

100% (4)

2

19

Female

Neck (nodal)

7.5 year history of mass; no follow-up available

38

54

65

70

Yes

—

—

3

61

Male

Retroperitoneal, colon

DFD at 15 months after diagnosis

33

27

70

30

No

—

—

4

56

Male

Liver

CT at time of primary diagnosis; SR at 9 months; CT for LR and M beginning at 21 months; AWD at 56 months after first diagnosis

31

42

90

55

Yes

5

75% (4)

5

60

Female

Porta hepatis, metastasis to omentum

CT at time of primary diagnosis; SDB for RPD and M at 17 months; no clinical follow-up available after SDB

31

27

40

55

No

2

100% (4)

6

60

Male

Chest wall

SR at time of primary diagnosis; SR and XRT for LR at 32 months; ANED at 61 months after first diagnosis

28

62

90

80

Yes

1

100% (4)a

7

22

Male

Neck (nodal)

No follow-up available

21

24

90

50

ND

—

—

8

40

Male

GI Mass, Duodenum

DFD at 29 months after diagnosis

20

38

70

35

ND

—

—

9

48

Male

Supraclavicular fossa

SR then XRT at time of primary diagnosis; CT for multiple LR and M beginning at 11 months; DFD at 37 months after first diagnosis

10

14

70

40

ND

3

100% (1)a

10

40

Female

Peritoneal

DFD at 32 months after diagnosis

5

18

70

20

No

—

—

11

26

Male

Tonsil/neck mass (nodal)

No follow-up available

4

14

60

20

ND

6b

—

12

77

Female

Ovary

No follow-up available

0

0

80

—

—

—

—

13

40

Female

Lymph node, Retroperitoneal

No follow-up available

0

0

60

—

—

—

—

14

66

Female

Lymph node, Periadnexal mass

Abdominal pain, no follow-up available

0

0

70

—

—

—

—

  1. Abbreviations: ANED, alive with no evidence of disease; AWD, alive with disease; CT, chemotherapy; DFD, dead from disease; LR, local recurrence; M, metastasis; ND, not determined; RPD, residual or progressive disease; SR, surgical resection; SDB, surgical debulking; XRT, radiation.
  2. aFollowing ploidy correction.
  3. bNo CNV data in Griffin et al.
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