Table 5 Analysis of dysplastic and metaplastic changes associated with small bowel carcinomas

From: Small bowel carcinomas in celiac or Crohn’s disease: distinctive histophenotypic, molecular and histogenetic patterns

 

Celiac disease carcinomas

Crohn’s disease carcinomas

Sporadic carcinomas

Total

Dysplasia

5/26 (19%)a

16/25 (64%)b

11/25 (44%)c

32/76 (42%)

 Metaplastic phenotyped

0/5 (0%)

14/15 (93%)

2/10 (20%)

16/30 (53%)

 β-Catenin nuclear expression

5/5 (100%)

0/13 (0%)

5/11 (45%)

10/29 (34%)

 SOX-9 expression

5/5 (100%)

10/13 (77%)

8/10 (80%)

23/28 (82%)

 MLH1 loss

1/5 (20%)

1/14 (7%)

0/10 (0%)

2/29 (7%)

 p53 overexpression

4/5 (80%)

7/15 (47%)

4/9 (44%)

15/29 (52%)

Non-dysplastic mucosa

    

 Metaplastic phenotyped

2/25 (9%)

19/22 (86%)e

0/24 (0%)

21/71 (30%)

  1. aPolypoid in one and flat in four cases.
  2. bPolypoid in eight, flat in five and minute foci in metaplasia in three cases.
  3. cPolypoid in 10 and flat in 1 case.
  4. dMetaplastic phenotype was defined as extensive MUC5AC and/or cytokeratin 7 expression.
  5. eP<0.001 vs either celiac disease-associated carcinomas or sporadic carcinomas.
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