Figure 1
From: FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate
Expression of FOXA2 mRNA is upregulated in human small cell neuroendocrine carcinoma. (a) Heatmap of a selection of genes in data sets of Beltran et al,20 Zhang et al,21 and Beltran et al 22 (contrast; log2 scale). (b) Relative expression of androgen-related genes (AR, KLK3, TMPRSS2, and ERG), Neuroendocrine-related genes (SYP, CHGA, and NCAM1), and FOXA2 at the time points after xenografting of LTL331 specimen in castrated mice in Akamatsu et al.23 LTL331R is a castrated resistant xenograft. SCNC, small cell neuroendocrine carcinoma.
