Table 1 Comparison of small cell neuroendocrine carcinoma specific biomarkers

From: FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate

Patient ID/tumor location

Chromogranin A

Synaptophysin

FOXA2

Patient #1/Dura

N

P

P

Patient #1/Liver

N

P

P

Patient #1/Periaortic LN

N

N

P

Patient #1/Supraclavicular LN

N

N

P

Patient #2/RT lung

N

N

P

Patient #3/Liver

N

P

P

Patient #4/Periaortic LN

N

P

P

Patient #5/Liver

N

N

P

Patent #6/Lung

N

N

N

SCNC-TMA #1/Prostate

N

N

P

SCNC-TMA #2/Prostate

P

P

P

SCNC-TMA #3/Prostate

P

P

P

SCNC-TMA #4/Prostate

N

N

P

SCNC-TMA #5/Prostate

P

P

P

SCNC-TMA #6/Prostate

N

N

P

SCNC-TMA #7/Prostate

P

P

P

SCNC-TMA #8/Prostate

N

N

P

SCNC-TMA #9/Prostate

N

P

P

SCNC-TMA #10/Prostate

N

P

P

SCNC-TMA #11/Prostate

P

P

P

 

5/20 (25%)

11/20 (55%)

19/20 (98%)

  1. Abbreviations: SCNC, small cell neuroendocrine carcinoma; LN, lymph node; TMA, tissue microarray; P, positive staining; N, negative staining.
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