Figure 2 | Modern Pathology

Figure 2

From: Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Figure 2

Differential gene expression analysis and pathway analysis of locally advanced rectal cancer resections in discovery cohort (n=40). (a) Principal component analysis of locally advanced rectal cancer resections by tumor regression grade shows separation of tumor regression grade 1 gene expression profiles and tumor regression grade 3 profiles. (b) Heatmap showing hierarchical clustering analysis of resections by 27 most differentially expressed genes, (blue denotes downregulated expression of genes and red upregulation), the heatmap depicts an upregulation of these genes in tumor regression grade 3 resections. (c) Ingenuity pathway analysis of 27 genes. Bar chart shows natural killer-cell signaling to be the most statistically enriched pathway. Legend—tumor regression grade 1 (red), tumor regression grade 2 (yellow) and tumor regression grade 3 (blue).

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