Figure 5 | Modern Pathology

Figure 5

From: Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Figure 5

The association between CD56 positive natural killer cells and tumor regression grade in post-therapeutic validation locally advanced rectal cancer tissue microarray (n=150) using immunohistochemistry. (a) Dot plot showing total counts of CD56 positive natural killer cells per tissue microarray core grouped by tumor regression grading (tumor regression grade 3 vs tumor regression grade 1). There was observed to be significantly more CD56 positive natural killer cells in tumor regression grade 3 resections compared with tumor regression grade 1 resections by Student's t-test P=0.0083. (b) Representative image of a CD56-positive immunohistochemistry in tissue microarray core of a tumor regression grade 3 responder with CD56 natural killer cells highlighted in yellow (× 40 magnification). (c) Representative image of a CD56-positive tissue microarray core by immunohistochemistry of a tumor regression grade 1 responder with CD56 natural killer cells highlighted in yellow (× 40 magnification).

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