Figure 2
From: EWSR1 fusion proteins mediate PAX7 expression in Ewing sarcoma
Whole-genome gene expression analyses identify PAX7 expression in Ewing sarcoma. (a) Heat-map of 7090 differentially expressed (>2-fold increased or decreased, FDR <0.01) genes in Ewing sarcoma versus CIC-DUX4 sarcoma. 12 CIC-DUX4 sarcomas and 6 EWSR1-NFATc2 Ewing sarcomas were clustered according to microarray-based gene expression signatures (GSE60740). (b) Volcano plot showing P-value versus fold-change in a comparison of high-throughput microarray gene expression data from 12 CIC-DUX4 sarcoma samples and 6 EWSR1-NFATc2 Ewing sarcoma samples. Each point on the plot represents one of 54675 individually analyzed loci. WT1 and PAX7 are highlighted as genes with significantly enriched expression in CIC-DUX4 sarcoma and Ewing sarcoma, respectively.
