Table 2 High confidence mutations and recurrent copy number variants identified by MSK-IMPACT, Ion AmpliSeq, or whole-exome sequencing

1

MSK-IMPACT

JAK

Missense mutation

p.V1009D

Yes

No

DNMT3A

Missense mutation

p.R181H

TET2

Missense mutation

p.E755K

ARHGAP26

Missense mutation

p.R103Q

ROR2

Missense mutation

p.R522Q

MLL2

Nonsense mutation

p.E3587*

2

MSK-IMPACT

MLL2

MLL2

Nonsense mutation

p.R2471*

No

No

Frame_Shift_Ins

p.L4518fs

3

MSK-IMPACT

NOTCH2

Missense mutation

p.N632S

Yes

No

IRF4

Missense mutation

p.E130G

DNMT3B

Missense mutation

p.G511C

BCOR

Frame_Shift_Ins

p.E1484fs

4

MSK-IMPACT

None

None

None

No

No

5

MSK-IMPACT

MAP2K1

Missense mutation

p.E51G

Yes

No

FAM123B

Splice_Site

p.Q2048fs

MLL3

Frame_Shift_Del

MAP2K1

In_Frame_Ins

p.59_60insQK

6

MSK-IMPACT

EPHA2

Missense mutation

p.A112T

Yes

No

BRCA2

Missense mutation

p.G1771D

7^a

MSK-IMPACT

PTEN

In_Frame_Del

p.T319

No

Yes

NPM1

Missense mutation

p.S125L

MLL3

Missense mutation

p.K992M

8

MSK-IMPACT

None

None

None

Yes

No

9

MSK-IMPACT

BAP1

Splice_Site

p.E577_splice

No

No

10

MSK-IMPACT

INPP4A

Missense mutation

p.N308T

No

Yes

KDR

Missense mutation

p.M559I

11^a

MSK-IMPACT

AXIN1

Missense mutation

p.E195*

No

No

BAP1

Missense mutation

p.R213H

FLT4

Splice_Site

p.P1023R

PBRM1

Missense mutation

12

MSK-IMPACT

XPO1

Missense mutation

p.L660F

No

No

13

MSK-IMPACT

PIK3CA

Missense mutation

p.G1049R

No

No

EED

Missense mutation

p.N194S

FGFR4

Frame_Shift

p.R464Pfs*32

14

MSK-IMPACT

PIK3CA

Missense mutation

p.H1047R

No

No

BAP1

Nonsense mutation

p.S319*

ATRX

Missense mutation

p.I47V

CRKL

Missense mutation

p.G136E

MLL1

Missense mutation

p.I962V

SPEN

Missense mutation

p.A3060V

15

MSK-IMPACT

SMARCA4

Missense mutation

p.R885C

No

Yes

NTRK1

Missense mutation

p.G181E

16 intraductal & invasive tumor

MSK-IMPACT

ZFHX3

Deletion

p.G3517_G3527del

No

No

17^a

MSK-IMPACT

None

None

None

Yes

No

18 primary pancreatic tumor

MSK-IMPACT

CEBPA

Missense mutation

p.R86P

No

No

18 recurrent pancreatic tumor

MSK-IMPACT

CDKN2A

Nonsense mutation

p.Y129*

No

No

RET

Missense mutation

p.L80R

18 celiac LN metastasis

MSK-IMPACT

None

None

None

No

No

19

Ion AmpliSeq

TRIP11

Missense mutation

p.L872H

Not applicable

Not applicable

20

Ion AmpliSeq

AXL

Missense mutation

p.R190H

Not applicable

Not applicable

PIK3CB

Missense mutation

p.L35V

21

Whole-exome seq

SYCP1

Splice site mutation

—

Yes

Yes

USH2A

Missense mutation

p.R878C

SLC4A10

Missense mutation

p.D208H

CTNNB1

Missense mutation

p.S45F

CBLB

Missense mutation

p.G259V

PIK3CA

Missense mutation

p.E545K

EPHB3

Missense mutation

p.Y855H

ETFDH

Missense mutation

p.G75D

FAT1

Missense mutation

p.E2401K

FAM170A

Missense mutation

p.R65C

HIST1H4K

Nonsense Mutation

p.E64*

MYB

Missense mutation

p.R73Q

MUC12

Missense mutation

p.N4428D

EHBP1L1

Missense mutation

p.R1138H

UBASH3B

Missense mutation

p.E257K

KCNA5

Missense mutation

p.A50V

TM7SF3

Frameshift Insertion

p.S246fs

CNTN1

Missense mutation

p.P271L

OSBPL8

Missense mutation

p.R318Q

CLK3

Nonsense Mutation

p.Y36*

TP53

Missense mutation

p.P113L

MYH13

Missense mutation

p.G203R

MYH8

Missense mutation

p.R1715H

KRT26

Missense mutation

p.R93C

JMJD6

Missense mutation

p.R95G

NOL4

Missense mutation

p.T119M

LTBP4

Missense mutation

p.G283D

ARHGAP35

Nonsense mutation

p.S975*

FAM71E2

Missense mutation

p.L329M

22^b

Whole-exome seq

CYR61

Missense mutation

p.C39*

CHML

Missense mutation

p.D210Y

SCN9A

Missense mutation

p.S1594T

KALRN

Missense mutation

p.A364T

COL6A6

Nonsense mutation

p.R1502H

PRR14L

Nonsense mutation

p.E658*

APC

Missense mutation

p.A2T

HIST1H3G

Missense mutation

p.M448K

WRN

Missense mutation

p.E226K

MUC2

Missense mutation

p.A59E

KRAS

Missense mutation

p.S286T

DNASE1L2

Missense mutation

p.S82F

NF1

Missense mutation

p.K1111T

ZNF208

Missense mutation

p.V30L

YES

YES