Figure 4
Expression of a 4-miRNAs signature predicts development of local recurrence in head and neck squamous cell carcinoma. Kaplan–Meier analysis representing the correlation between the expressions of four miRNAs considered as a group and recurrence-free survival in peritumoral (a) and tumoral (b) tissues of head and neck squamous cell carcinoma patients (see Materials and methods for score calculation). Kaplan–Meier analyses were performed comparing patients with high expression of the signature and patients with low expression of the signature, according to the expression level of each prognostic miRNA (see Materials and methods). (c) Kaplan–Meier analysis representing the correlation between the expression levels of four miRNAs considered as a group and recurrence-free survival in normal tissues. (d) Kaplan–Meier analysis representing the correlation between the expression levels of four miRNAs considered as a group and recurrence-free survival by the combination of their expression in tumor and peritumoral tissues of head and neck squamous cell carcinoma patients. Kaplan–Meier analyses were performed dividing the patients in four subsets: patients with high expression of the miRNA signature for both tissues (tumor and peritumor), patients with high expression in tumor and low expression in peritumor and vice versa, and finally patients with low expression of the signature in both tissues. The P-value was calculated on the two subgroups expressing high and low level of miRNAs signature in both tissues (tumor and peritumor). The multivatiate Cox analysis relative to recurrence-free-survival is shown at the bottom of each KM.
