Table 1 Drugs perturbation analysis by LINCS database of mRNAs correlated to at least one of four prognostic miRs

From: Altered peritumoral microRNA expression predicts head and neck cancer patients with a high risk of recurrence

Drug family

Name of drug

Statins

Simvastatin

mTOR and mTORC inhibitors

Sirolimus, AZD8055, KU-0063794, NVP-BEZ235, Wortmannin

Actin filament polymerization inhibitors

Cytochalasin b

PI3Ks inhibitors

Wortmannin, AS605240, KU-0060648, PI-103, PI-828, PP-110, TGX-115

EGFR inhibitor

WZ-3146

Cox-2 inhibitor

Valdecoxib

IGF1R inhibitor

BMSF754807, BMS536924

 

BMSF536924

MEK1, MEK2

PD-198306, selumetineb

Inhibitors of sphingolipid metabolism

DL-PDMP

  1. Mean rank score (best four cell lines) >90 for positive score and <−90 for negative score. We selected only the drugs able to negatively perturb mRNAs-PC as well as positively perturb mRNAs-NC.
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