Figure 1 | Modern Pathology

Figure 1

From: Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database

Figure 1

Tumors reclassified based on integration of morphology and genetics; whole-slide images from http://cancer.digitalslidearchive.net/: (a) TFE3 translocation-associated renal cell carcinoma, composed of cells with clear cytoplasm arranged in large nests with hyalized stroma. (b) TFE3 translocation-associated renal cell carcinoma with papillae, foamy macrophages, and psammoma bodies. (c) Papillary renal cell carcinoma with compact architecture, clear cytoplasmic changes, and admixed foamy macrophages. (d) Papillary renal cell carcinoma with well-formed papillae. By report, a clear cell renal cell carcinoma component was present in this patient, but this was not visualized in the available tumor slide images. (e, f) Clear cell papillary renal cell carcinoma, composed of branched glandular structures and broad papillae.

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