Figure 4
From: Pathologic assessment of gastrointestinal tract and pancreatic carcinoma after neoadjuvant therapy
(a) Neoadjuvant treatment of hepatic colorectal carcinoma metastases often demonstrate fibrosis within the center of the lesion with viable tumor seen at the periphery (× 20). (b) This metastatic tumor demonstrated abundant necrosis that should not be regarded as indicative of treatment response. This metastatic tumor was regarded as having no response to treatment. (c) In this example, there is minor response with obvious residual tumor but abundant fibrosis. (d) Only rare tumor cells are seen in this metastatic tumor deposit, indicative of a major response.
