Table 2 Schemes for tumor regression grade in hepatic colorectal metastases after neoadjuvant therapy

From: Pathologic assessment of gastrointestinal tract and pancreatic carcinoma after neoadjuvant therapy

Tumor regression grading scheme (references)

Score

Criteria

Rubbia-Brandt52

Major response

Fibrosis without detectable tumor; or fibrosis with rare, scattered residual cancer cells

 

Minor response

Fibrosis and tumor cells with a predominance of fibrosis

 

No response

Fibrosis and tumor cells with a predominance of tumor cells, or no changes of regression

Blazer55

Complete response

No residual carcinoma

 

Major response

1–50% residual carcinoma

 

Minor response

>50% residual carcinoma