Table 1 Clinicopathologic and molecular features of GNAS-mutated lung adenocarcinoma
From: GNAS mutations in primary mucinous and non-mucinous lung adenocarcinomas
Case | Age | Sex | Smoking | Stage | Histotype | TTF1 | GNAS | Raf/Ras | TP53 | CDKN2A |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 60 | F | Current | IV | ACA | + | p.Gln227His | − | p.Gly245Cys | c.457C>A |
2 | 71 | F | Former | IV | ACA | + | p.Gln227Leu | − | p.Tyr220Cys | – |
3 | 66 | M | Former | I | ACA | + | p.Gln227Leu | − | p.Gln100a | – |
4 | 74 | F | Former | I | ACA | NA | p.Gln227Leu | − | – | – |
5 | 67 | F | Former | III | ACA | + | p.Gln227Leu | KRAS p.Gly12Cys | – | – |
6 | 78 | F | Former | III | ACA | NA | p.Arg201His | − | p.Arg249Gly | – |
7 | 62 | F | Former | IV | ACAa | − | p.Arg201Leu | HRAS p.Gln61Arg | c.783-1G>T | – |
8 | 69 | F | Former | IV | ACA | + | p.Arg201His | BRAF p.Gly469Ala | – | – |
9 | 58 | F | Former | IV | ACA | + | p.Arg201Ser | − | p.Arg273Leu | – |
10 | 49 | F | Never | I | IMA | + | p.Arg201His | BRAF p.Val600Glu | − | – |
11 | 59 | F | Former | I | IMA | − | p.Arg201Cys | KRAS p.Gly12Cys | – | – |
12 | 70 | M | Former | I | IMA | − | p.Arg201Cys | KRAS p.Gly12Asp | − | – |
13 | 37 | F | Never | IV | IMA | NA | p.Arg201His | KRAS p.Gly12Asp | p.Phe113Leu | – |
14 | 24 | F | Never | II | IMA | NA | p.Arg201Cys | KRAS p.Gly12Asp | – | – |
15 | 55 | F | Never | I | IMA | NA | p.Arg201Cys | KRAS p.Gly12Val | – | – |
16 | 67 | F | Never | I | IMA | NA | p.Arg201His | KRAS p.Gly12Asp | – | – |
17 | 76 | F | Never | I | IMA | NA | p.Arg201Cys | KRAS p.Gly13Asp | – | p.Asp68fs |
18 | 75 | F | Never | IV | IMA | NA | p.Arg201His | KRAS p.Gly12Asp | – | – |
19 | 48 | M | Never | II | IMA | – | p.Arg201Cys | KRAS p.Gly12Asp | – | p.Met54fs |
