Table 1 Summary of clinical and pathological features of the studied oral cavity squamous cell carcinoma cohorts

From: An oral cavity squamous cell carcinoma quantitative histomorphometric-based image classifier of nuclear morphology can risk stratify patients for disease-specific survival

 

Entire cohort N (%)

Modeling set N (%)

Test set N (%)

P-value

No. of patients

115

50

65

 

Age

61.0±12.0

62.9±13.3

59.5±10.7

0.1545

Sex

   

0.0006

 Female

63 (54.8)

18 (36.0)

45 (69.2)

 

 Male

52 (45.2)

32 (64.0)

20 (30.7)

 

Race

   

0.8530

 White

54 (47.0)

24 (48.0)

30 (46.2)

 

 Other

61 (53.0)

26 (52.0)

35 (53.8)

 

Smoking

   

1

 Ever

29 (90.6)

16 (94.1)

13 (86.7)

 

 Never

3 (9.4)

1 (5.9)

2 (13.3)

 

Comorbidity score

   

0.8263

 None/mild

59 (64.8)

26 (52.0)

33 (50.8)

 

 Moderate/severe

32 (35.2)

13 (26.0)

19 (29.2)

 

Treatment

   

0.1494

 Surgery only

33 (29.7)

11 (22.0)

22 (33.9)

 

 Postoperative or definitive

78 (70.3)

38 (76.0)

40 (61.5)

 

Pathology histology

   

0.8262

 Well/moderately differentiated

88 (76.5)

39 (78.0)

49 (75.4)

 

 Poorly differentiated

27 (23.5)

11 (22.0)

16 (24.6)

 

N-stage

   

0.5492

 N0/N1

75 (66.4)

35 (70.0)

40 (61.5)

 

 N2

38 (33.6)

15 (30.0)

23 (35.4)

 

N-stage

   

0.7055

 N0

55 (48.7)

23 (46.0)

32 (50.8)

 

 N1/N2

58 (51.3)

27 (54.0)

31 (49.2)

 

T-stage

   

0.3433

 T1/T2

64 (57.1)

26 (52.0)

38 (58.5)

 

 T3/T4

48 (42.9)

24 (48.0)

24 (36.9)

 

Margin

   

0.4762

 Negative

91 (80.5)

37 (74.0)

54 (83.1)

 

 Positive

22 (19.5)

11 (22.0)

11 (16.9)

 

Chemotherapy

   

0.2321

 No

78(67.0)

34 (68.0)

44 (67.7)

 

 Yes

22 (33.0)

13 (26.0)

9 (13.9)

 

Patient status

   

0.2577

 Alive

69 (60.0)

27 (54.0)

42 (64.6)

 

 Dead

46 (40.0)

23 (46.0)

23 (35.4)

 

Disease recurrence

   

0.1330

 No

85 (73.9)

33 (66.0)

52 (80.0)

 

 Yes

30 (26.1)

17 (34.0)

13 (20.0)

 
  1. Value in bold is statistically significantly different between the Modeling and Test sets, P<0.05.