Figure 1 | Modern Pathology

Figure 1

From: Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Figure 1

TFEB-amplified renal cell carcinomas with representative immunohistochemical stains. (a) In-house TFEB-amplified renal cell carcinoma with features of poorly differentiated carcinoma (Case 4), H&E, × 100 (inset: TFEB FISH demonstrating amplification); (b) H&E, × 400. Immunohistochemical work-up demonstrated (c) patchy Melan-A expression, × 400, and (d) patchy pancytokeratin expression, × 400. Similarly, Case 2 also demonstrated predominantly nested architecture and resembled high-grade clear cell renal cell carcinoma (e) H&E, × 200. Case 3 showed oncocytic and papillary morphology (f) H&E, × 200.

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