Figure 3 | Modern Pathology

Figure 3

From: Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Figure 3

TFEB translocation renal cell carcinomas. Two tumors (a, b) show nested architecture and entrapped benign renal tubules, one (a) with the classic biphasic morphology including smaller cells surrounding basement membrane material. H&E, × 200. Inset of (a) shows TFEB FISH with split red and green signals indicating translocation. Two tumors (c, f), show papillary architecture. One (c) shows serrated eosinophilic epithelium and prominent lymphocytic infiltrate without significant collections of histiocytes within papillary cores, H&E, × 200, inset: H&E, × 400. Immunohistochemical stains demonstrate case (c) to be (d) negative for Melan-A, × 200 and (e) diffusely positive for pancytokeratin, × 200. Case (f) is positive for Melan-A (inset of f).

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