Figure 4 | Modern Pathology

Figure 4

From: Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Figure 4

Morphologic spectrum of TFE3 translocation renal cell carcinoma, including (a) classic TFE3 translocation renal cell carcinoma morphology, H&E, × 200, inset: TFE3 FISH demonstrating split red and green signals indicating TFE3 translocation; (b) oncocytic renal cell carcinoma with cystic architecture, H&E, × 200, inset: H&E, × 400; (c) subnuclear clearing and linear nuclear array, H&E, × 200, inset: high World Health Organization/International Society of Urological Pathology nucleolar grade, H&E, × 400; (d) extensive subnuclear clearing and linear nuclear array, H&E, × 400; (e) extensive tubular architecture, H&E, × 200; and (f) metastasis to liver with biphasic appearance including central swirled spindle cells, H&E, × 100, inset: H&E, × 200.

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