Figure 6 | Modern Pathology

Figure 6

From: Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Figure 6

TFE3 translocation renal cell carcinoma arising in a horseshoe kidney, with biphasic morphology (a, b), H&E, × 200. The tumor is composed predominantly of cells with eosinophilic to clear cytoplasm, eccentric nuclei, and large vacuoles (c, d), H&E, × 400 (inset highlights vacuoles), with focal pockets of eosinophilic cells with high nucleus-to-cytoplasm ratio (e), H&E, × 400 (inset highlights increased nucleus-to-cytoplasm ratio). Other areas of the tumor mimic high-grade clear cell renal cell carcinoma (f), H&E, × 200.

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