Table 1 Detailed morphology of renal cell carcinoma cases submitted for TFE3 and/or TFEB FISH

From: Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

 

TFE3 translocation (n=21)

TFEB translocation (n=4)

TFEB amplification (n=6)

No detected MITF aberration (n=54)

Predominant nested architecture

7/21 (33%)

2/4 (50%)

2/6 (33%)

13/54 (24%)

Predominant papillary architecture

8/21 (38%)

2/4 (50%)

4/6 (67%)

21/54 (39%)

Predominant pseudopapillary architecture

4/21 (19%)

0/4 (0%)

0/6 (0%)

17/54 (32%)

Predominant solid architecture

0/20 (0%)

0/4 (0%)

0/6 (0%)

2/54 (4%)

Predominant cystic architecture

1/21 (5%)

0/4 (0%)

0/6 (0%)

0/54 (0%)

Predominant trabecular architecture

0/20 (0%)

0/4 (0%)

0/6 (0%)

1/54 (2%)

Predominant tubular architecture

1/21 (5%)

0/4 (0%)

0/6 (0%)

0/54 (0%)

Entrapped benign renal tubules

4/20 (20%)

4/4 (100%)

3/6 (50%)

16/52 (31%)

Dual (eosinophilic and clear) cytoplasmic tones

16/21 (76%)

4/4 (100%)

5/6 (83%)

31/54 (57%)

Biphasic TFEB t-RCC-like

4/21 (19%)

2/4 (50%)

0/6 (0%)a

0/54 (0%)

Subnuclear clearing and linear nuclear array

7/21 (33%)

0/4 (0%)

0/6 (0%)b

4/54 (7%)

Oncocytic features

5/21 (24%)

0/4 (0%)

4/6 (67%)

22/54 (41%)

Voluminous clear and/or eosinophilic cytoplasm

19/21 (91%)

3/4 (75%)

4/6 (67%)

37/54 (69%)

Psammomatous calcifications

14/21 (67%)

4/4 (100%)

1/6 (17%)

14/54 (26%)

Foamy histiocytes

4/21 (19%)

0/4 (0%)

3/6 (50%)

22/54 (41%)

Necrosis

9/21 (43%)

1/4 (25%)

4/6 (67%)

26/54 (48%)

Sarcomatoid differentiation

2/21 (10%)

0/4 (0%)

1/6 (17%)

5/54 (9%)

Nuclear pseudoinclusions

12/21 (57%)c

1/4 (25%)

3/6 (50%)c

9/54 (17%)c

Cytoplasmic vacuolization

19/21 (91%)

4/4 (100%)

6/6 (100%)

47/54 (87%)

  1. aOne case had foci with smaller cells forming acinar structures, but no basement membrane material.
  2. bFour additional cases had foci with orderly polarization of nuclei in the mid to apical aspects of oncocytic cells.
  3. cNuclear pseudoinclusions were extensive in focal nodules in 1 of 12 TFE3 translocation RCCs with this feature. Of the remaining cases with nuclear pseudoinclusions, this feature was extensive in one of three TFEB-amplified RCCs and one of nine RCCs without a detected MITF aberration.
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