Table 4 Polymorphisms associated with relative reduction of HAM-D21 score after 8-week antidepressant treatment with desipramine or fluoxetine

From: Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans

Medication

Gene

SNP

Chromo- some

Position

SNP type

Genotype

N

Mean (s.d.)

Deltaa (95% CI)

P b

FDR_BH c

Desipramine or fluoxetine

ABCB1

rs2214103

7

87062884

INT

CC

132

64.26 (21.35)

21.45 (5.29–37.61)

0.01

0.72

      

CG

8

46.44 (32.92)

   
 

NTRK2

rs9969765

9

86679605

INT, 3′ UTR

CC

46

69.48 (19.13)

10.96 (3.11–18.81)

0.007

0.72

      

GG/CG

87

58.79 (23.81)

   
  

rs2289657

9

86753280

SYN

CC

106

65.38 (20.35)

12.74 (3.32–22.15)

0.009

0.72

      

AA/AC

26

52.48 (29.11)

   
 

SLC6A2

NT_010498.15_9300464

16

54243766

Upstream

TG

15

77.25 (21.72)

18.49 (6.60–30.39)

0.003

0.72

      

TT

121

60.69 (22.06)

   

Desipramine

SLC6A3

rs8179029

5

1462985

INT

CC

54

61.32 (20.05)

29.79 (9.04–50.54)

0.007

0.56

      

TT/TC

6

27.05 (39.26)

   
 

NTRK2

rs7038236

9

86678222

INT, 3′ UTR

CC

37

63.52 (18.98)

16.97 (4.73–29.22)

0.009

0.56

      

AA/AC

18

48.02 (24.77)

   
  

rs11140793

9

86681300

INT, 3′ UTR

AA

43

62.71 (23.47)

18.30 (5.74–30.86)

0.006

0.56

      

CC/AC

22

46.39 (23.30)

   
  

rs2289658

9

86753190

INT, splice site

TT

44

62.94 (20.19)

18.00 (5.32–30.69)

0.007

0.56

      

CC/TC

20

43.57 (27.86)

   
  

rs2289657

9

86753280

SYN

CC

51

62.11 (19.93)

26.83 (13.39–40.27)

0.0002

0.05

      

AA/AC

13

36.40 (29.89)

   
  

rs56142442

9

86826085

SYN

CC

59

60.70 (19.89)

33.17 (17.15–49.19)

0.0001

0.05

      

TT/TC

8

28.92 (34.90)

   

Fluoxetine

SLC6A2

NT_010498.15_9300464

16

54243766

Upstream

TG

10

85.09 (13.13)

20.55 (8.23–32.87)

0.002

0.46

      

TT

60

65.69 (18.37)

   
  

rs4783899

16

54244713

Upstream

TT

24

76.99 (15.15)

15.02 (5.37–24.68)

0.003

0.47

      

GG/TG

48

64.22 (20.09)

   
  1. Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; CI, confidence interval; HAM-D21, 21-item Hamilton Depression Rating Scale; INT, intronic; NTRK2, neurotrophic tyrosine kinase type 2 receptor; SNP, single nucleotide polymorphism; UTR, untranslated region; SYN, synonymous.
  2. aDelta: adjusted mean difference in relative reduction of HAM-D21 score.
  3. bP: based on general linear model after controlling for age, gender and baseline HAM-D21 score.
  4. cBenjamini-Hochberg false discovery rate after correcting for multiple testing.
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