Table 5 Haplotypes associated with depression or clinical remission after 8-week antidepressant treatment

From: Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans

Sample

Gene

Block no.

Haplotype a

Frequency

χ2

d.f.

P

    

Case

Control

   

MDD patients and healthy controls

CREB1

Block 1

GCACGG

0.003

0.018

5.71

1

0.02

 

SLC6A3

Block 1

CGTGCGGT

0.089

0.134

4.83

1

0.03

 

ABCB1

Block 2

GCACACACGAGAC

0.060

0.028

6.12

1

0.01

 

NTRK2

Block 1

GTTAGGGCA

0.094

0.133

3.96

1

0.05

 

SLC6A2

Block 3

ACCAGA

0.004

0.017

3.98

1

0.05

    

Remitter

Non-remitter

   

MDD patients treated with desipramine or fluoxetine

ABCB1

Block 1

ACA

0.101

0.029

4.72

1

0.03

 

NTRK2

Block 3

TCG

0.839

0.717

5.63

1

0.02

 

SLC6A4

Block 1

TAGC

0.006

0.047

5.11

1

0.02

  

Block 1

TAGA

0.048

0.003

4.92

1

0.03

  

Block 2

ATTGTAACC

0.028

0.081

4.00

1

0.05

MDD patients treated with desipramine

ABCB1

Block 1

ACA

0.132

0.018

5.31

1

0.02

 

NTRK2

Block 3

TCG

0.865

0.679

6.35

1

0.01

  

Block 3

CAG

0.045

0.177

5.74

1

0.02

 

SLC6A2

Block 3

GCCAGT

0.134

0.012

6.79

1

0.009

MDD patients treated with fluoxetine

ABCB1

Block 2

GCGCACACGAGAC

0.503

0.682

4.08

1

0.04

 

SLC6A4

Block 1

TAGC

0.000

0.085

8.37

1

0.004

  1. Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; CREB1, cyclic AMP-responsive element binding protein 1; MDD, major depressive disorder; NTRK2, neurotrophic tyrosine kinase type 2 receptor; SNP, single nucleotide polymorphism.
  2. aLetters with underline indicate the SNPs also showing an association with a nominal P<0.05 in the corresponding SNP-based analysis.
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