Table 2 Results of replication analysis
Marker name | Allele 1 | Allele 2 | Chr. | Position | Gene | Discovery (N=18 176) | Replication (N=7929) | Meta-analysis (discovery+replication) fixed effect | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | σβ | P-value | β | σβ | P-value | β | σβ | P-value | ||||||
rs2470893 | t | c | 15 | 72806502 | CYP1A1/CYP1A2 | 0.0614 | 0.011 | 2.39 × 10 −08 | 0.0986 | 0.024 | 7.2 × 10 −05 | 0.0675 | 0.010 | 1.6 × 10 −11 |
rs2472297 | t | c | 15 | 72814933 | CYP1A1/CYP1A2 | 0.0671 | 0.012 | 4.18 × 10 −08 | 0.1396 | 0.032 | 1.9 × 10 −05 | 0.076 | 0.011 | 2.7 × 10 −11 |
rs6495122 | a | c | 15 | 72912698 | CPLX3/ULK3 | −0.0551 | 0.010 | 8.22 × 10−08 | −0.0375 | 0.016 | 0.020 | −0.05 | 0.008 | 7.1 × 10 −09 |
rs16868941 | a | g | 8 | 103121553 | NCALD | 0.0648 | 0.0124 | 1.55 × 10−07 | 0.0018 | 0.031 | 0.954 | 0.056 | 0.011 | 8.2 × 10−07 |
rs382140 | a | g | 7 | 107569436 | LAMB4/NRCAM | 0.0729 | 0.0143 | 3.34 × 10−07 | 0.1351 | 0.042 | 1.4 × 10 −03 | 0.079 | 0.014 | 3.9 × 10 −09 |
rs9526558 | a | g | 13 | 48880513 | CAB39L | 0.0595 | 0.012 | 6.79 × 10−07 | NA | NA | NA | NA | NA | NA |
