Figure 2
From: Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
The effects of sertraline on neuronal differentiation are dependent on the glucocorticoid receptor (GR). The GR-antagonist RU486 (50 nM) abolished the effect of SERT (1 μM) and of DEX (1 μM) on the number of microtubulin-associated protein-2 (MAP2)-positive neurons (a) and on the number of doublecortin (Dcx)-positive neuroblasts (b). Three independent experiments were conducted on three independent cultures (n=3), four wells were analyzed per treatment condition in each experiment, and three non-overlapping pictures were analyzed per well. All data are mean±s.e.m. *P<0.05, **P<0.01 compared with SERT or DEX-treatment alone.
