Figure 3
Brain activation by a palatable food stimulus, and the effects of GSK1521498 and naltrexone on food reward-related activation in selected regions of interest. (a) Whole-brain map of brain regions activated by experimental contrast between palatable food stimulus and purified water; z indicates distance (mm) superior or inferior to the inter-commissural plane in standard stereotactic space. (b) Bar chart showing magnitude of blood oxygenation level-dependent (BOLD) activation by palatable stimuli versus purified water in nine pre-specified regions of interests: amygdala (AMG), caudate (CAU), globus pallidus (GLP), hippocampus (HIP), insula (INS), nucleus accumbens (NAC), orbitofrontal cortex (OFC), putamen (PUT) and thalamus (THA). (c) Bar chart showing magnitude of change in food-related activation, Δ-BOLD, following treatment with GSK1521498 or naltrexone (NTX) in the same nine regions of interest. (d) Plots of BOLD activation by palatable stimuli versus receptor occupancy from pre- and post-dose scans for each participant in each of the treatment groups. Asterisks (*) denote effects that are significantly different from 0 at P<0.05 (Bonferroni corrected). MOR, mu opioid receptor.
