Figure 1
AKT1 and memory-dependent hippocampal activity. (a) Main effect of the AKT1 rs1130233 variant on hippocampal activity during implicit encoding of complex visual scenes (coordinates −19 −41 4; n=96, t=3.66, P<0.05 corrected within the medial temporal lobe (MTL) region-of-interest), where individuals carrying the A-allele had relatively increased activation compared with G homozygotes. (b) Extracted parameter estimates from the hippocampal brain region showing the main task effect also evidenced AKT1-by-BDNF interaction (F(1,92)=4.70, P=0.033). Individuals carrying the BDNF-Met allele (n=32) had an accentuated AKT1 A-carrier effect (n=15). (c) Further conditioning the AKT1–BDNF interaction on COMT Val/Met at this same hippocampal location resulted in an AKT1-by-BDNF-by-COMT interaction (F(1,90)=4.77, P=0.032). Here, the AKT1 A-allele effect was accentuated in individuals who were COMT-Val homozygotes and carrying the BDNF-Met allele (n=9), relative to effects in BDNF-Val homozygotes and/or COMT-Met carriers. Error bars are ±1 s.e.
