Figure 2
AKT1 and medial temporal lobe (MTL) gray-matter volume. (a) Main effects of AKT1 rs1130233 A-allele on reduced gray-matter volumes in left and right MTL regions (n=171; coordinates −9 −5 −34, t=3.14; coordinates 36 15 −33, t=3.10, displayed at P<0.001 uncorrected). (b) Extracted parameter estimates from the left and right MTL peaks showing the main AKT1 effects also evidenced AKT1-by-COMT interactions (F(1,162)=4.66, P=0.032 and F(1,162)=4.69, P=0.032 for the left and right loci, respectively). Individuals with combined AKT1 A carriers and COMT-Val homozygotes (n=17) had disproportionately reduced gray-matter volumes at these loci. This set of results were permutation corrected P<0.001 within bilateral MTL regions-of-interest. Error bars are ±1 s.e.
