Table 2 List of 15 most contributory (Table 2a) and 15 most protective (Table 2b) SNPs for ASD diagnosis in the CEU Cohort

From: Predicting the diagnosis of autism spectrum disorder using gene pathway analysis

SNP	Weight lower (0.95)	Weight	Weight higher (0.95)	delta	Gene number	Gene symbol
(a) Risk SNPs and their weightings
rs968122	1.5465	1.5555	1.5645	0.0090	27 345	KCNMB4
rs876619	0.9476	1.2092	1.4708	0.2616	2775	GNAO1
rs11020772	0.8553	0.8641	0.8729	0.0088	2915	GRM5
rs9288685	0.5856	0.5998	0.6140	0.0142	3635	INPP5D
rs10193128	0.5836	0.5946	0.6056	0.0110	3635	INPP5D
rs7842798	0.5298	0.5386	0.5474	0.0088	114	ADCY8
rs3773540	0.5125	0.5208	0.5291	0.0083	55 799	CACNA2D3
rs1818106	0.5002	0.5161	0.5320	0.0159	80 310	PDGFD
rs2384061	0.4195	0.4306	0.4417	0.0111	109	ADCY3
rs12582971	0.3983	0.4295	0.4607	0.0312	5288	PIK3C2G
rs10409541	0.4067	0.4189	0.4311	0.0122	773	CACNA1A
rs2300497	0.3782	0.3889	0.3996	0.0107	801	CALM1
rs7562445	0.3741	0.3843	0.3945	0.0102	2066	ERBB4
rs7313997	0.3382	0.3567	0.3752	0.0185	5801	PTPRR
rs2239118	0.3348	0.3552	0.3756	0.0204	775	CACNA1C
(b) Protective SNPs and their weightings
rs17629494	−0.5242	−0.5070	−0.4898	0.0172	5592	PRKG1
rs4648135	−0.5807	−0.5260	−0.4713	0.0547	4790	NFKB1
rs17643974	−0.5527	−0.5424	−0.5321	0.0103	1488	CTBP2
rs1243679	−0.5771	−0.5674	−0.5577	0.0097	341 799	OR6S1
rs2240228	−0.5942	−0.5816	−0.5690	0.0126	26 532	OR10H3
rs260808	−0.5938	−0.5836	−0.5734	0.0102	80 310	PDGFD
rs4128941	−0.6166	−0.6082	−0.5998	0.0084	8313	AXIN2
rs769052	−0.6321	−0.6235	−0.6149	0.0086	7322	UBE2D2
rs984371	−0.7273	−0.7181	−0.7089	0.0092	219 437	OR5L1
rs4308342	−1.0196	−0.8938	−0.7680	0.1258	1633	DCK
rs11145506	−0.9400	−0.9172	−0.8944	0.0228	9630	GNA14
rs905646	−0.9700	−0.9624	−0.9548	0.0076	2915	GRM5
rs6483362	−0.9894	−0.9661	−0.9428	0.0233	2915	GRM5
rs12317962	−1.4869	−1.3200	−1.1531	0.1669	27 345	KCNMB4
rs8053370	−1.7162	−1.6956	−1.6750	0.0206	2775	GNAO1

Abbreviations: ASD, Autism spectrum disorder; CEU, of Central (Western and Northern) European origin; SNP, single-nucleotide polymorphism.
Weight indicates the contribution of each SNP to ASD clinical status. ‘Weight lower’ indicates the 0.95 lower error bar of the estimate; ‘Weight higher’ indicates the 0.95 upper error bar for that SNP. Note that some genes have SNPs that contribute to risk for ASD and SNPs that protect against ASD.

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Table 2 List of 15 most contributory (Table 2a) and 15 most protective (Table 2b) SNPs for ASD diagnosis in the CEU Cohort

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