Figure 1 | Molecular Psychiatry

Figure 1

From: Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors

Figure 1

Tree analyses performed to assess MDD risk in cluster of variants. Eight nsSNPs had high-order interactions in the control of tree growth; they are located in the following genes: HSD3B1, PDLIM5, PSMD9, BDNF, USP36, PDE6C, PSMB4 and MYOC genes. Light-pink nodes=low MDD risk; light-green nodes=moderate MDD risk; light-blue nodes=high MDD risk; and purple node=reference MDD risk. Sensitivity=40%, specificity=83% and accuracy=63% (sensitivity refers to the proportion of cases who are correctly predicted as case; specificity refers to the proportion of controls who are correctly predicted as control; and accuracy refers to the proportion of cases and controls who are correctly predicted as case or control).

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